![]() The seats are limited, so make sure to get your free ticket now! Of course you will have plenty of time for Q&A and networking. We will guide you through the strengths of Merlin Project, Merlin Server and how they are working together. All rights reserved.These free of charge and interactive events will introduce Merlin Project as the leading project management software on Mac and iPhone. In particular, we aimed at demonstrating the feasibility of building complex realistic exposure scenarios and the accuracy of the modelling predictions through a comparison with actual measurements.Įxposure MERLIN-Expo Multimedia modelling PBPK Uncertainty.Ĭopyright © 2016 Elsevier B.V. One of the objectives of the 4FUN project was also to increase the confidence in the applicability of the MERLIN-Expo tool through targeted realistic case studies. Standardized documentation for each model and training material were prepared to support an accurate use of the tool by end-users. These models can be linked together to create flexible scenarios relevant for both human and wildlife biota exposure. MERLIN-Expo is composed of a library of fate models dedicated to non biological receptor media (surface waters, soils, outdoor air), biological media of concern for humans (several cultivated crops, mammals, milk, fish), as well as wildlife biota (primary producers in rivers, invertebrates, fish) and humans. The availability of such tools for uncertainty and sensitivity analysis aimed to facilitate the incorporation of such issues in future decision making (iii) the integration of human and wildlife biota targets with common fate modelling in the environment. MERLIN-Expo thus allows the determination of internal effective chemical concentrations (ii) the incorporation of a set of functionalities for uncertainty/sensitivity analysis, from screening to variance-based approaches. The main challenges in exposure modelling that MERLIN-Expo has tackled are: (i) the integration of multimedia (MM) models simulating the fate of chemicals in environmental media, and of physiologically based pharmacokinetic (PBPK) models simulating the fate of chemicals in human body. This paper describes the main features of the MERLIN-Expo tool. MERLIN-Expo is a library of models that was developed in the frame of the FP7 EU project 4FUN in order to provide an integrated assessment tool for state-of-the-art exposure assessment for environment, biota and humans, allowing the detection of scientific uncertainties at each step of the exposure process. 12 Istituto di Chimica Agraria ed Ambientale, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122, Piacenza, Italy.11 Enviresearch Ltd., Herschel Building/Nanotechnology Centre, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.10 AIEFORIA srl, via Gramsci 22, 43036 Fidenza (PR), Italy.9 Arche cvba, Liefkensstraat 35d, 9032 Gent (Wondelgem), Belgium. ![]()
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